I know a little about self-publishing, having bought "How to Self-Publish Your Own Comic Book" by Tony Caputo a few months ago, and following numerous articles online in the past. But, getting into direct market distribution and newsstand distribution, subscriptions, promotion, marketing, etc, etc, etc sounds like a LOT of work for one person, especially one who is writing, drawing, lettering, editing, and publishing the book in question.
Some of the scenarios in the book illustrate scenarios where the publisher makes phone calls to comic shop owners across the US to find out their thoughts on the quality and the sales at the store level. To boost sales, Caputo suggests holding a signing and offering free signed copies to the store to sell.
In this day and age, a self-publisher is up against time, the only unwavering force in the universe. It's like climbing a mountain covered in snow before your boots made of paper towels get wet. There's just so much to take care of, not including the work that goes into the actual making of the comic.
Anyway, that is why I am considering taking my comic to a publisher who is already established. Soon, I'll be pitching the idea and showing some sample pages to some publishers in hopes of getting the idea picked up. I have a backup plan, which involves a lot more promotion, sales, etc, but not to the extent of someone actually taking on the role of "self-publisher" in the traditional sense. More on that later.